In this review, we empathize with the current scenario, recent advancements, and enduring challenges of the susceptibility of four significant genes [ACE2, (IL-2, 7, 10), TNF, and VEGF] associated with COVID-19 are progressively involved in the development of ASRD, SARS, and other respiratory problems according to their function (Table 2). This evidence concerns the gene ACE2 and COVID-19.