FTO and obesity due to melanocortin 4 receptor deficiency: Our analyses identified three genomic areas of particular interest: (a) a male-specific association for BMI-adjusted NC within an intergenic region between genes NOG and C17orf67, a locus which previously was associated with height; (b) a sex-combined association for BMI-adjusted NC with a SNP in gene PDZRN3, a locus previously associated with the ECG-derived PR interval; and (c) an association in BMI-unadjusted analyses of NC with a SNP in the FTO gene, which harbors multiple SNPs associated with energy intake and obesity [35].