Studies in vitro have demonstrated that EGCG upregulated the expression of differentiation markers (CD11B and CD15) and differentiation-inducing genes (CEBPE and CSF3R); the co-treatment of APL cells with ATRA plus EGCG enhanced neutrophil differentiation1, and EGCG further decreased the expression of PML/RARα in these cells14,32,33. This evidence concerns the gene RARA and acute promyelocytic leukemia.