TNF and cystic fibrosis: Vaccine strategies that (1) develop NTM-specific antigen candidates that are immunogenic in humans and (2) devise focused regimens with respect to different disease indications (e.g. Cystic Fibrosis (CF) or anti-TNF-therapy, scenarios with defects in mechanical or physical disruptions to the pulmonary space as well as those with disrupted proinflammatory signaling), have the capacity to significantly impact the burden of NTM disease.