MAPT and Alzheimer disease: Three eSNPs in eQTLs involving HLA-DRB1/HLA-DRB5 (rs9271058) and ARL17A/LRRC37A2 (rs2732703 and rs113986870, which are near KANSL1 and MAPT) were previously associated with AD risk at the genome-wide significance level24,28 (Table 1).