One of the eGenes in this top-ranked group (HLA-DRB5) is an established AD gene, and three others that are near established AD loci (DLG2 near PICALM29, C4BPA near CR130, and MYO1E near ADAM1031) are reasonable AD gene candidates based on evidence using non-genetic approaches (Table 3). Here, HLA-DRB5 is linked to Alzheimer disease.