For example, eQTLs observed in undifferentiated brain cells involving CR1 paired with rs6656401 (P = 7.85 × 10−22), in endothelial cells involving HLA-DRB1 paired with rs73399473 (P = 2.5 × 10−10) and HLA-DRB5 paired with rs1064697 (P = 2.18 × 10−14), in microglia involving HLA-DRB1 paired with rs72847627 (P = 4.43 × 10−51), and in neurons involving ECHDC3 paired with rs866770710 (P = 5.79 × 10−13) were significant only in AD cases (Supplementary Table 12B). This evidence concerns the gene CR1 and Alzheimer disease.