For instance, A1 receptors is overexpressed in renal cell carcinoma (RCC), and treatment with A1 receptors antagonist DPCPX inhibits RCC progression.264 Both A2A and A2B receptors highly expressed in neuroendocrine tumours promote proliferation of cancer cells.265 Activation of A3 receptors in glioblastoma increases the migration and invasion of cancer cells under hypoxia.266 As an immunosuppressive factor, adenosine supports tumour growth, at least partially. The gene discussed is IGKV2D-29; the disease is renal cell carcinoma.