For example, the TT genotype at rs2298383 SNP in A2A receptor predicts lower risk of depression compared to the CC or CT genotypes.196 The rs2230912 polymorphism also causes a Gln460Arg mutation in P2X7 receptor, which is associated with depression.197 These SNPs are believed to serve as potential indicators for early risk assessment of depressive disorders. Here, P2RX7 is linked to depressive disorder.