Among these SNPs, the T139I on HNF4A upregulates its ability to activate ABCG2 promoter, leading to ABCG2 overexpression, which is negatively associated with serum urate level.56 Such genetic modifications are much more complicated, thus again highlighting the importance of a balanced diet in the prevention and relieve of hyperuricemia. The gene discussed is ABCG2; the disease is hyperuricemia.