Hypertriglyceridemia can be caused by not only triglyceride synthesis, storage and degradation deficiency resulted by inherited inborn error of metabolism, but also secondary obesity, diabetes, liver diseases, hypothyroidism, etc.[8] GPD1 gene encodes cytoplasmic NAD-dependent GPD1 and catalyzes the reversible redox reaction of DHAP and nicotine adenine dinucleotide (NADH) to G3P and NAD+, playing a crucial role in carbohydrate and lipid metabolism,[1] its mutation is one of the major causes for primary hypertriglyceridemia with onset in infancy. Here, GPD1 is linked to hypothyroidism.