Blood and urine test: C-reactive protein, coagulation function, tumor marker, and thyroid -stimulating hormone level were all normal; immunoglobulin G of 667 mg/dl (normal range, 751–1560 mg/dl), total hemolytic complement of 54.7 U/ml (normal range, 23.0–52.0 U/ml); thyroglobulin-negative and anti-thyroglobulin antibody-positive, as well as anti-SSB antibody-positive. The gene discussed is TG; the disease is neoplasm.