An ulcer is often formed on the mass's surface, mostly blue-black or gray-black, and 10% to 23% of the masses are non-pigmented.[4] Virginal malignant melanoma can be diagnosed by immunohistochemistry, S-100, HMB-45, and melanoma-associated antigen recognized by T cells (MART-1)—the latter 2 are most commonly used because of their specificity.[5] Vaginal malignant melanoma is characterized by an extremely high degree of malignancy and invasiveness, high difficulty in treatment, high rate of recurrence and metastasis, and poor prognosis. Here, PMEL is linked to melanoma.