The Prostate Cancer Intervention versus Observation Trial (PIVOT) trial showed no survival benefit from radical prostatectomy in men with PSA ≤ 10 μg/L,[4] which are based on D’Amico criteria as a combination of PSA < 10 μg/L, stage ≤ T2A and Gleason score ≤ 6. Here, PROS1 is linked to Familial prostate cancer.