Wei et al reported that rs3750996/rs3750994 in STIM1 are significantly correlated with higher inflammation in ankylosing spondylitis patients.[31] Another strong piece of evidence comes from a demonstration that STIM1 promotes colorectal cancer cell migration by increasing the expression of cyclooxygenase-2 and prostaglandin E2.[32,33] In light of this mounting evidence, our functional annotation implied the possibility of SOC-mediated EPO resistance via inflammatory regulation. The gene discussed is EPO; the disease is colorectal cancer.