NFKB1 and hypertensive disorder: In the inflammatory process associated with hypertension, inappropriate activation of the NF-kB pathway facilitates disease progression by inducing inflammatory cytokine release, vascular dysfunction, and generation of ROS [39, 53] The TLR signaling pathway, a critical upstream mechanism activating inflammatory signaling, regulates inflammatory response by promoting the release of a variety of inflammatory mediators, inducing the migration of immune cells to inflammatory sites, and increasing the adhesion and infiltration ability of inflammatory cells [36, 54].