Our integrative approach elucidated the potential mechanisms of GZD against hypertension based on a systematic network perspective, and demonstrated that GZD can effectively attenuate elevated blood pressure, improve both inflammatory cell infiltration and myocardial fibrosis, and inhibit the expression levels of IL-6, CCL2, IL-1β, MMP-2, and MMP-9 in the Dahl salt-sensitive rats. Here, IL6 is linked to hypertensive disorder.