INS and hypertensive disorder: As depicted in Fig. 4d, the KEGG pathways of GZD against hypertension were mainly related to the tumor necrosis factor (TNF) signaling pathway, hypoxia-inducible factor 1 (HIF-1) signaling pathway, Toll-like receptor (TLR) signaling pathway, insulin resistance, PI3K-AKT signaling pathway, and nuclear factor kappa-B (NF-ĸB) signaling pathway.