RHOA and cardiac hypertrophy: Mechanistically, RhoA/ROCK signaling has been shown to induce cardiac hypertrophy via AngII-receptor-mediated vasoconstriction, probably facilitated by RhoGEFs expressed in VSMCs (PDZ-RhoGEF, LARG and p115RhoGEF) [91, 156] (Figs. 3 and 4).