RHOA and cardiomyopathy: To achieve this, a search of pertinent literature was done using online tools (PubMed, ScienceDirect and Web of Science) to screen multiple databases and by a specific search in top journals, with the following main keywords: RhoA, Rho GTPase, Rho/Rac/Cdc42, ROCK; alone and/or in combination with one or more other of these keyword(s): small GTPase, heart, cardiomyopathy, hypertrophy, GEF, GAP, GDI, GDF, GPCR-activation, PE, AngII, ET, TAC, animal-model, signal transduction, fetal genes, fibrosis, apoptosis, contractility.