In the present study, we investigated the SH3PXD2B mRNA transcription and protein expression in The Cancer Genomics Atlas (TCGA) and the Human Protein Atlas, a proteome database, as well as clinical HCC specimens, and analyzed their association with overall survival (OS) and recurrence-free survival (RFS) of HCC patients. This evidence concerns the gene SH3PXD2B and hepatocellular carcinoma.