Based on our recruited 89 HCC patients, higher levels of SH3PXD2B protein expression were significantly associated with positive HBsAg detection (P = 0.004), higher Edmondson-Steiner grades (P = 0.023), higher TNM stages (P = 0.037), higher Ki-67 expression (P = 0.040), and higher AFP expression (P = 0.030), but not with other characteristics in this population (Table 1). The gene discussed is AFP; the disease is hepatocellular carcinoma.