SH3PXD2B and hepatocellular carcinoma: We found that transduction of HCC Hep3B and Huh7 cells with lentivirus for expression SH3PXD2B-specific shRNA significantly decreased the relative levels of SH3PXD2B expression by 52%-64%, compared with the control cells (both P < 0.05, Fig. 3a–d).