According to univariate regression analyses, significant correlation was observed between tumor size (HR: 2.664, 95%CI: 1.424–4.983, P = 0.002), AFP (HR: 2.310, 95%CI: 1.253–4.258, P = 0.007), vascular invasion (HR: 2.327, 95%CI: 1.261–4.293, P = 0.007), BCLC stage (HR: 2.543, 95%CI: 1.248–5.181, P = 0.010), ALT (HR: 2.082, 95%CI: 1.046–4.146, P = 0.037), GGT (HR: 3.825, 95%CI: 1.697–8.626, P = 0.001), coNLR-PDW (HR: 3.342, 95%CI: 1.960–5.699, P < 0.001) and OS. The gene discussed is AFP; the disease is neoplasm.