In an additional study, we found that aberrant CLDN6 expression promotes the malignant phenotypes of endometrial cancer in vitro and in vivo via hijacking the CLDN6–ERα axis.83 For instance, we demonstrated that abnormal CLDN6–ERα signaling stimulates not only cell proliferation but also collective cell migration in the leading front of endometrial cancer cells. Here, ESR1 is linked to endometrial cancer.