Of note, vitamin D may decrease the risk of SARS-CoV-2 infection and protect against the symptoms of COVID-19 by inhibiting the synthesis of renin (a proteolytic enzyme and a positive regulator of Ang II) and by increasing ACE2 expression and Ang-(1–7) production in the lung, thus preventing Ang II accumulation, decreasing the pro-inflammatory activity of Ang II and reducing the risk of ARDS, myocarditis and cardiac injury [47,49]. Here, REN is linked to COVID-19.