TP53 and acute myeloid leukemia: Our previous experiments demonstrated that EGCG could up-regulate the expression of p19Arf, p53, and p21Cip1 to induce apoptosis in acute myeloid leukemia cells, confirming that the p19Arf-p53-p21Cip1 signaling pathway mediated EGCG-induced apoptosis (Wu et al., 2020).