The present study revealed for the first time that EGCG enhanced the inhibition of proliferation, invasion of DDP in gastric cancer cells, and promoted the cell apoptosis through up-regulating the expression of p19Arf, p53, p21Cip1 via the p19Arf-p53-p21Cip1 signaling pathway. This evidence concerns the gene CDKN2A and gastric cancer.