Previous studies conducted on the association among serum, intracellular, and extracellular levels of this factor showed that the IL-8 level significantly increases in the presence of malignancies such as melanoma, breast carcinoma, ovarian malignancies, and pancreatic cancer (Green et al., 1996; Chen et al., 2014; Chia et al., 2014; Yung et al., 2018). The gene discussed is CXCL8; the disease is melanoma.