In this study we tried to evaluate the Immunohistochemical expression of VDR and CTLA4 antidodies and their role in breast cancer of Egyptian patients as there is a great controversy about their role in suppression or promotion of breast cancer (Zhang et al., 2014; Murray et al., 2017; Tavera-Mendoza et al., 2017; Xu et al., 2018). This evidence concerns the gene VDR and breast cancer.