On the other hand there is significant association between high CTLA4 expression in tumor cells and poor prognostic parameters as advanced tumor stage (T4) and presence of vascular invasion (P= 0.01 and 0.05 respectively), also a trend of significance with advanced nodal stage (N2 and N3) (P= 0.07) (Table 6). This evidence concerns the gene CTLA4 and neoplasm.