VEGFA and neoplasm: Also, hypoxia induces vascular endothelial growth factor (VEGF) in tumor cells and induces matrix metalloproteinase (MMP) expression in endothelial cells, leading to angiogenesis and tumor cell invasion (Dong, 2019).Certain therapeutic strategies are needed to be applied as a mono-treatment or in combination with chemotherapeutic drugs to overcome hypoxia and angiogenesis.