As regard clinical outcome of AML cases according to combined CXCR4 positivity and SDF-1 genotypes, no significant differences between the 4 groups and between CXCR4 negative with SDF1 (G\G) alleles genotype AML patients versus disconcordant versus CXCR4 positive with SDF-1(A) allele carrier genotype AML patients were found in clinical outcome Table 5. The gene discussed is CXCR4; the disease is acute myeloid leukemia.