When stratifying AML into 4 groups according CXCR4 positivity and SDF1 gene polymorphisms, CXCR4positive with SDF-1 (A) allele carrier genotype AML patients had significantly higher incidence of toxic manifestations (p 0.023) and lower CR (p 0.016) versus CXCR4negative with SDF-1 (G\G) alleles genotype AML patients and disconcordant respectively. The gene discussed is CXCL12; the disease is acute myeloid leukemia.