Indeed, in a recent single-center Brazilian study involving 99 adult patients with hypopituitarism, around half of the patients had nontumoral causes of hypopituitarism, while FSH/LH, GH, TSH, and ACTH deficiencies were present in 99%, 98.6%, 96%, and 81.8% of them, respectively (12). Here, PLOD1 is linked to hypopituitarism.