For instance, metformin, an oral diabetes drug operating at the molecular level, inhibits the mitochondrial respiratory chain in the liver leading to the activation of adenosine monophosphate-activated protein kinase (AMPK), and eventually enhancing insulin sensitivity [7], which causes significant side effects including anorexia, nausea, abdominal discomfort, and diarrhea [8]. This evidence concerns the gene INS and diabetes mellitus.