We compared HSV-1 infection of LCs and Epi-cDC2s in the presence of an anti-langerin neutralizing antibody, at two concentrations, and found that LCs had a significant reduction in infection (to 62.3 ± 8.7%) in the presence of the antibody, whereas for Epi-cDC2s no reduction in infection was observed (104.7 ± 8.9%), even though a small subset of the Epi-cDC2s expressed low levels of langerin (Fig 7C). Here, CD207 is linked to infection.