Fourteen genes (LINC01116, GPNMB, CSTA, S100A4, CHI3L1, TIMP3, VAMP8, HOXC6, MEOX2, CD36, POSTN, CRLF1, SERPINF1, ST6GALNAC5) were up-regulated in both IPF and ADC and six genes (CHRDL1, TRIM55, ACAN, CHRM2, PCOLCE2, RARRES1) were down-regulated in both IPF and ADC in comparison to control (Fig 1A). The gene discussed is ACAN; the disease is idiopathic pulmonary fibrosis.