The human orthologs of MgtE, the SLC41 proteins (SLC41A1, SLC41A2, and SLC41A3), also transport Mg2+ ions [10,18–20], and mutations in these proteins are associated with type 2 diabetes [21], Parkinson disease [22], and nephronophthisis [23]. The gene discussed is SLC41A1; the disease is nephronophthisis.