In addition to controlling glucose metabolism, PKM2 also regulates hypoxia-inducible factor-1α (HIF-1α), β-catenin (β-cat), epidermal growth factor (EGFR), signal transductors, transcriptional activators 3 (STAT3), and other cancer-related factors, thereby promoting cell growth and proliferation [39–41]. This evidence concerns the gene HIF1A and cancer.