By examining the resected tumor tissue, we found that the lactate content in the tumor tissue of the lovastatin-treated group was significantly higher by 25% ± 8.1% (p = 0.006) (Fig 1D); the levels of VEGF and glutathione (GSH) in the tissues were also significantly increased (Fig 1E and 1F). This evidence concerns the gene VEGFA and neoplasm.