Interestingly, PKM2 can also enhance tumor angiogenesis by activating nuclear factor-κB (NF-κB) and HIF-1α and by triggering the secretion of VEGF-A [18], although we did not detect any significant change in HIF-1α at any time point in either our in vivo or in vitro experiments. Here, NFKB1 is linked to neoplasm.