ANGPT1 and Hypertension: Sustained hypertension is known to compromise the BBB (Setiadi et al., 2018), and, as the rats in this study were 11–12 weeks of age at the start of the experiment it is uncertain whether their BBB was still functioning normally, thereby affecting the ability of Ang 1‐7 or iodoAng 1‐7 to penetrate the BBB.