ANGPT1 and hypertensive disorder: Given that SHR develops hypertension at the early age of 4–5 weeks (Dickhout & Lee, 1998; Harrap et al., 1990; Heijnen et al., 2014) and the blood‐brain‐barrier (BBB) is compromised in young SHR due to the high BP exerted upon the brain vasculature (Ueno et al., 2004), Ang 1‐7 may be able to enter the SHR brain to a greater extent than in normotensive rats.