At 12 and 24 hpi, single‐molecule RNA FISH was performed using probes specific for the SARS‐CoV‐2 genome and for ISG15 which was found to be highly upregulated upon infection and has the highest ‐log10 P‐value in the differential analysis comparing bystander cells vs mock‐infected cells (Fig 4G). The gene discussed is ISG15; the disease is infection.