In the context of insulin resistance, although one study found Mdivi‐1 transiently enhanced skeletal muscle insulin signaling in a genetic model of obese mice (Jheng et al., 2012), the efficacy of prolonged administration of Mdivi‐1 as a pharmacological approach to inhibit Drp1 and improve skeletal muscle insulin sensitivity in obesity and insulin resistance has not been fully investigated. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.