INS and Obesity: In the context of insulin resistance, although one study found Mdivi‐1 transiently enhanced skeletal muscle insulin signaling in a genetic model of obese mice (Jheng et al., 2012), the efficacy of prolonged administration of Mdivi‐1 as a pharmacological approach to inhibit Drp1 and improve skeletal muscle insulin sensitivity in obesity and insulin resistance has not been fully investigated.