In the development of obesity‐induced insulin resistance, mounting evidence indicates that excessive Drp1‐mediated mitochondrial fission is negatively correlated with skeletal muscle insulin action and whole‐body insulin sensitivity (Fealy et al., 2014; Jheng et al., 2012; Kugler et al., 2020). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.