The beneficial effects of Drp1 inhibition are in line with previous work, including ours that demonstrated the inverse relationship between Drp1 activity and skeletal muscle insulin sensitivity (Fealy et al., 2014; Kugler et al., 2020), as well as a study showing that single Mdivi‐1 injection transiently (i.e., 1 h prior to sacrifice) enhanced insulin signaling in a genetic model of obesity (Jheng et al., 2012). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.