Through the study of a rare genetic condition in humans, neonatal progeroid syndrome (NPS, also known as marfanoid–progeroid–lipodystrophy syndrome), we recently discovered a fasting-induced, glucogenic, and orexigenic hormone that is the C-terminal cleavage product of profibrillin (encoded by FBN1) and named it asprosin (Romere et al., 2016). This evidence concerns the gene FBN1 and Wiedemann-Rautenstrauch syndrome.