Anti-asprosin mAbs neutralize not only the circulating asprosin in different MS mouse models (Romere et al., 2016; Duerrschmid et al., 2017), but also asprosin-mediated hepatic cAMP signaling and AgRP neuron activity, demonstrating neutralization of asprosin action by all three mAbs at the level of both its functions – orexigenic and glucogenic. The gene discussed is FBN1; the disease is myeloid sarcoma.