Interestingly, repeating this experiment in lean C57BL/6 mice (with normal plasma asprosin compared with DIO mice) showed a subtle effect on blood glucose without inducing hypoglycemia, and no effect at all on 24 hr cumulative food intake or body weight (Figure 1—figure supplement 3), suggesting that elevation in plasma asprosin or presence of florid MS may be necessary prerequisites to unlocking the full therapeutic effect of asprosin neutralization. The gene discussed is FBN1; the disease is Hypoglycemia.