We recently discovered a novel glucogenic and orexigenic hormone, named asprosin, whose circulating levels are elevated in mice, rats, and humans with MS (Romere et al., 2016; Li et al., 2019; Duerrschmid et al., 2017; Wang et al., 2020a; Ugur and Aydin, 2019; Alan et al., 2019; Zhang et al., 2019; Baykus et al., 2019). The gene discussed is FBN1; the disease is myeloid sarcoma.