Additionally, the results of western blotting analysis for the expression of RAB18 indicated dramatical upregulation of protein and mRNA RAB18 levels in U251-MG, U87-MG, U373-MG and T98G cells compared with HA cells (Figure 1(b,c)), implying that RAB18 plays an essential role in glioma development. The gene discussed is RAB18; the disease is glioma.