STXBP1 and Lennox-Gastaut syndrome: On the contrary, it suggests that it might have a differential involvement for aberrant activity propagation and control across neurological conditions, including Lennox-Gastaut syndrome or patients with absence seizures [39], patients with several comorbid psychiatric conditions (e.g., Tourette syndrome) [40, 41], or in patients with specific gene mutations (STXBP1 and SCN2A) as evidenced in animal models of such conditions [42].