We found increased CSF orexin A concentrations in bvFTD patients (mean: 0.226 ng/mL ± SD: 0.103) compared to controls (mean: 0.139 ng/mL ± SD: 0.058), and this resulted statistically significant (p < 0.001) (Fig. 1), also when adjusted for age and sex (p < 0.001). Here, HCRT is linked to behavioral variant of frontotemporal dementia.