Motivated by the synergy observed between ZD55-IL-24 and PD-1 blockade in local tumors, we further sought to evaluate whether ZD55-IL-24 was also able to synergize with PD-1 blockade to reject the distant uninjected tumors in B16-bearing immunocompetent mouse model using a bilateral flank B16 tumor model [23]. The gene discussed is PDCD1; the disease is neoplasm.