AP2M1 and myelodysplastic syndrome: In a larger, more recent study, Reilly et al. [21] analyzed 10 patients with del5q in their cohort of 141 MDS patients and found genes in the respective cluster were mostly hypermethylated; especially, the genes WT1, NBEA (Neurobeachin), and AP1M2 (Adaptor Related Protein Complex 1 Subunit Mu 2) were significantly differentially methylated.