NCR1 and influenza: Three patients with severe H1N1/09 influenza had low pbNK cell counts, with one lethal case of a pregnant women with IAV viremia, scarce infiltration of lung tissues with immune cells and a total absence of NK cells in lung samples.100 IAV could also directly infect human pbNK cells, induce their apoptosis, and downregulate NKp46- and NKp30-mediated cytotoxicity.101,102 Conversely, upon co-incubation of pbNK with H1N1-infected autologous monocytes, pbNK cells isolated from pregnant individuals produced higher levels of IFN-ɣ and degranulated more than pbNK cells isolated from control women.