Based on the in silico drug sensitivity test and serologic characteristics, we hypothesized that the two PCa specific serum markers PSA and PAP combination can predict molecular subtypes and drug responses of mCRPC patients: the KLK3/ACP3 mRNA expression ratio is lowest in AVPC-M and lumina A subtypes that are predicted to be docetaxel-resistant (Fig. 4c). The gene discussed is KLK3; the disease is posterior cortical atrophy.