To begin to define the relationship between atherosclerosis inflammation resolution and gut microbiome characteristics, we used an established murine model14 in which donor atherosclerotic aortic arches from hyperlipidemic Apoe−/− mice are transplanted into the abdominal aorta of wild-type (WT) recipient mice; in the WT milieu, plaques regress14. The gene discussed is APOE; the disease is atherosclerosis.