B-ALL was divided into three risk groups based on the classifications presented in a previous study11: (1) Good risk; ETV6-RUNX1 and high hyperdiploidy (51–65 chromosomes); (2) Intermediate risk; TCF3-PBX1, IGH translocations and B-other (none of these established abnormalities); and (3) High risk; BCR-ABL1, KMT2A translocations, near haploidy (30–39 chromosomes), low hypodiploidy (less than 30 chromosomes), iAMP21, and TCF3-HLF. This evidence concerns the gene HLF and acute lymphoblastic leukemia.