The most common (> 10%) genetic alterations of B-ALL were CDKN2A/B (31%), NRAS (17%), IKZF1 (17%), PAX5 (16%), ETV6 (15%), FLT3 (14%), ERG (12%), and RB1 (11%). The gene discussed is CDKN2A; the disease is acute lymphoblastic leukemia.