To determine whether NK depletion affects the magnitude of the anti-influenza CD8+ T cell response, we monitored the accumulation of the immunodominant anti-influenza nucleoprotein (NP)-specific CD8+ T cells in the lung, lung airways (via bronchial alveolar lavage (BAL)), and lung-draining mediastinal lymph nodes (MdLN) after infection in the presence or absence of NK cells. Here, CD8A is linked to infection.