Given that TRM cells produce significant IFN-γ in the lung prior to the recruitment of reactivated peripheral Tmem and the known contribution of CD8+ TRM cells in protection against heterosubtypic influenza infection5, our data suggests that positioning more CD8+ TRM cells at the site of infection can control viral titers without the need for reactivation of peripheral Tmem cells. This evidence concerns the gene CD8A and infection.