A role for TRMO encoding a tRNA methyltransferase involved in tRNA processing, and for NANS involved in sialic acid synthesis process in tumorigenesis has not been evidenced so far although variation in the expression of the two genes has been observed in thyroid carcinoma according to TCGA transcriptomic data, suggesting that further studies on these candidates should be pursued. Here, NANS is linked to thyroid gland carcinoma.