IGFBP5 and neoplasm: Interestingly, the top SNP for DIRC3, rs16857611, is an eQTL which downregulates the expression of DIRC3 and the expression of its neighboring tumor suppressor gene IGFBP5 whose product belongs to a family of proteins which interacts with insulin-like growth factors (IGFs) involved in regulation of vital processes such as cell proliferation, differentiation and apoptosis.