GLP-1RAs treatment was recently shown to upregulate mRNA expression of proteins that ameliorated disease condition in a murine inflammatory bowel disease model and it was suggested that GLP-1RAs may affect gut homeostasis also in the distal parts of the gut.19 However, it remains to be elucidated if other cells, in addition to myenteric plexus neurons, in the colon also express the GLP-1R in mice and other species. This evidence concerns the gene GLP1R and inflammatory bowel disease.