CD8A and Alzheimer disease: The comparison with gene ontology (GO) terms showed at 25% FDR, significant methylation differences in females were enriched in 25 GO biological processes (Table 4, Additional file 2: Table S10), many of which are involved in inflammatory responses associated with AD pathology including CD8 positive alpha beta T cell activation and interferon alpha production, as well as other biological processes critical for AD pathogenesis such as response to platelet derived growth factor and positive regulation of axon extension.