TYROBP and Alzheimer disease: The TYROBP causal network was previously inferred from a large-scale network analysis of human late-onset AD brains [56]; it was FDR significant (P-value < 0.001, FDR = 0.014) in females (Additional file 1: Fig. S4a), compared to a nominal association in males (P-value < 0.001, FDR = 0.620).