Recently, Li et al. [146] also reported that promotor methylation of insulin-like growth factor binding protein 7 (IGFBP7) in the cfDNA is an independent risk factor for 155 patients undergoing surgical resection, indicating that continuous detection of tumor-specific driver gene mutations and methylation in ctDNA can be unrestricted by genetic heterogeneity and achieve the prediction goal of HCC. The gene discussed is IGFBP7; the disease is neoplasm.