STAT4 and hepatocellular carcinoma: Specific mutations in the HLA region, KIF1B, STAT4, GRIK1, ErbB2, TP53, and PTEN are mainly found in HCC caused by HBV [117], and the genomic aberration of HCC samples in the region of TP53 and GPCR subfamily members (ADGRB1, ADGRB2, and ADGRB3) are closely related to aflatoxin B1 [118].