It has been reported that TERT promoter (51%), TP53 (32%), CTNNB1 (17%), PTEN (8%), AXIN1 (6%), ARID2 (6%), KMT2D (6%), and TSC2 (6%) were prevalent in ctDNA analysis of 121 advanced HCC patients according to targeted ultra-deep sequencing [60]. The gene discussed is KMT2D; the disease is hepatocellular carcinoma.