TP53 and hepatocellular carcinoma: Another study relied on ddPCR technology to identify four hot-spot mutants (TP53-rs28934572, TRET-rs1242535815, CTNNB1-rs121913412, and CTNNB1-rs121913401) and arrived at a similar conclusion that specific aberrations displayed in ctDNA can be defined as an independent risk factor of HCC patients for post-operative recurrence [88].