To date, the description of the genomic landscape of HCC patients at an early stage is mainly derived from the excised surgical tissues, and the recurrent genomic alterations are TERT, TP53, CDKN2A, CTNNB1, AXIN1, ARID1A, ARID2, MLL2, NFE2L2, and KEAP1 [58]. This evidence concerns the gene KMT2D and hepatocellular carcinoma.