Shaoyan Chang et al. investigated the alterations of eighteen imprinted genes germline differential methylation regions (gDMRs) methylation in patients with CHD and found altered gDMR methylation level of 8 imprinted genes, including 2 imprinted genes with hypermethylation of GRB10 and MEST and 6 genes with hypomethylation of PEG10, NAP1L5, INPP5F, PLAGL1, NESP and MEG3. This evidence concerns the gene NAP1L5 and coronary artery disorder.