TXNRD2 and cardiovascular disorder: Among the 52 genes identified, DUSP27 (dual specificity phosphatase 27), RUNX1 (runt-related transcription factor 1) and TXNRD2 (thioredoxin reductase 2) play an important role during muscle and heart development [126–128], APOA5 and PCSK9 are associated with cardiovascular disease[129–131], while many have not been reported to be associated with AVS in previous studies.