RENBP and infection: Based on these studies, it is likely that the one dog in our study that had D. repens Mf and converted from HW Ag negative to positive post-HT was a result of cross-reactivity; however, we cannot rule out the possibility that this dog was also infected with HW and the infection was identified post-HT, as co-infection with D. repens and D. immitis is common in areas where both occur [6].