In non-survivors with pre-existing CAD, the median levels of BNP and hs-TNI within the first week showed a higher fold change (BNP: 5.8; hs-TNI: 7.5; α-HBDH: 1.9; CK-MB: 0.81; LDH: 1.7) from the upper reference limit of each marker (Fig. 6a). This evidence concerns the gene NPPB and coronary artery disorder.