Of note, the VEN/8-Cl-Ado combination increased activation of the cyclin-dependent kinase inhibitor p21, decreased the proliferation marker PCNA (Fig. 2c), augmented DNA fragmentation and enhanced apoptosis in the CD34+/CD38− AML blasts after 48 h of treatment (Fig. 2d). Here, CD34 is linked to acute myeloid leukemia.