To test the VEN/8-Cl-Ado combination in vivo, we then engrafted NSG mice with FLT3‐ITD MV4-11-Luc AML cells 7 days prior to start of treatment with vehicle control, 50 mg/kg/day daily 8-Cl-Ado (via Alzet osmotic pump), 20 mg/kg/day 5x/week oral VEN, or 8-Cl-Ado plus VEN. This evidence concerns the gene FLT3 and acute myeloid leukemia.